Redesigning of drug in Unani Formulations
Unani System of Medicine (USM), prescribes elaborate pharmaceutical processing of drugs to achieve palatability, stability absorption and assimilability, and to enhance the safety and efficacy of drugs. These objectives are obtained not only by developing various dosage forms on rationale and experimental bases but also by devising many processing (Tadabeer) techniques. This pharmaceutical processing is applied to both single (single ingredients) preparations and compound (multiple ingredient) preparations. It also has a unique speciality of adding corrective drugs (musleh advia) to counter the toxicity of main drugs. Now a days these drugs are being manufactured mostly in the classical form. Modern instruments are used in preparation of drugs. Sometimes minor alterations are made in the dosage form and due care in mind not to depart from the original essence. GMP (Good Manufacturing Practices) are followed in order to ensure quality of these drugs.
Unani medicine since its origin passed through many stages, countries, cultures and civilizations. It contains not only Greek, Roman, Egyptian, Arabic, Persian and Indian origin drugs and formulations but from several parts of the world. So wide variety of drugs/ mixture of drugs from different parts of world is available in Unani texts. It is duty of Unani medicine physicians/ experts to prescribe best treatment through best available drugs to the suffering humanity. Ilmul Advia (Unani Pharmacology) is an important wing of Unani system of Medicine. It is related to the identification of drugs, their pharmacological actions and uses of Mufradat (single drugs) as well as Murakkabat (compound formulations). It also includes Saidla (Unani Pharmacy) which guides in proper way to prepare Murakkabat (compound formulations).
What is Drug Designing
Drug designing is one of the major concerns in any system of medicine as it is not just the efficacy and potency of any drug formulation that plays a pivotal role, but shape, taste, colour etc. also plays an important role in the intake of any medicine. This becomes more concerning in our Unani System of Medicine (USM) in the present era with special emphasis on Unani Drug Formulations.
Drug design also known as rational drug design or rational design is an splendid inventive process of new medication on the basis of biological targets. That is the invention in medical history in order to yield significant therapeutic response which enhances the therapeutic benefits of new drugs.
All other System of Medicines has modified their formulation according to the need, but in USM formulations are maintained at the same stage as they were discovered. We cannot deny the formulations made by our eminent Unani Formulations, but we need to change them according to the need today e.g Diabetes is now one of the major prevalent disease that has been now more common, so if we continue using our Unani Formulations as Majoon, Khameera, Jawarish etc. which contains 70-80% Sugar in it; it will definitely worsen the condition; and this is one of the profound reason of Why USM is not exercised at a level where it should be. Although Sugar in these type of formulations used was due to their preservation, taste correction, etc. but when it is worsening we